×
Entrez Id:
7422
Gene Symbol:
VEGFA
VEGFA
0.220
AlteredExpression
phenotype
LHGDN
[Correlation between vascular endothelial growth factor and peritumoural edema in meningiomas].
12425822
2002
×
Entrez Id:
7422
Gene Symbol:
VEGFA
VEGFA
0.220
AlteredExpression
phenotype
LHGDN
Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas.
18317686
2008
×
Entrez Id:
4318
Gene Symbol:
MMP9
MMP9
0.500
Therapeutic
phenotype
CTD_human
Increased hemorrhage and brain edema that correlated with higher mortality and neurologic deficits were found in MMP-9 -knockout mice.
15529013
2004
×
Entrez Id:
9423
Gene Symbol:
NTN1
NTN1
0.300
Therapeutic
phenotype
CTD_human
Knockdown of endogenous NTN-1 increased expression of pro-inflammatory mediators and MPO, and aggravated neuroinflammation and brain edema .
29162556
2018
×
Entrez Id:
3606
Gene Symbol:
IL18
IL18
0.200
Therapeutic
phenotype
RGD
Interleukin-18 attenuates disruption of brain-blood barrier induced by status epilepticus within the rat piriform cortex in interferon-γ independent pathway.
22338606
2012
×
Entrez Id:
6833
Gene Symbol:
ABCC8
ABCC8
0.200
Therapeutic
phenotype
RGD
Inhibition of SUR1 decreases the vascular permeability of cerebral metastases.
23633925
2013
×
Entrez Id:
5328
Gene Symbol:
PLAU
PLAU
0.500
Biomarker
phenotype
CTD_human
Massive cerebral edema after recanalization post-thrombolysis.
11677890
2001
×
Entrez Id:
4318
Gene Symbol:
MMP9
MMP9
0.500
Biomarker
phenotype
RGD
Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema.
20541575
2010
×
Entrez Id:
6285
Gene Symbol:
S100B
S100B
0.500
Biomarker
phenotype
CTD_human
The single measurement of serum S100B at 6 h after ICH induction was significantly correlated with brain edema formation and the maximal extent of the hematoma volumes.
19027832
2009
×
Entrez Id:
6285
Gene Symbol:
S100B
S100B
0.500
Biomarker
phenotype
RGD
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.
19147496
2009
×
Entrez Id:
5328
Gene Symbol:
PLAU
PLAU
0.500
Biomarker
phenotype
RGD
Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury.
18718505
2008
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.300
Biomarker
phenotype
CTD_human
Tumor necrosis factor-α (TNF-α) augments AMPA-induced Purkinje neuron toxicity.
21276434
2011
×
Entrez Id:
10398
Gene Symbol:
MYL9
MYL9
0.300
Biomarker
phenotype
CTD_human
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption.
17419808
2007
×
Entrez Id:
4843
Gene Symbol:
NOS2
NOS2
0.300
Biomarker
phenotype
CTD_human
Decreased brain edema after collagenase-induced intracerebral hemorrhage in mice lacking the inducible nitric oxide synthase gene. Laboratory investigation.
19374494
2009
×
Entrez Id:
4638
Gene Symbol:
MYLK
MYLK
0.300
Biomarker
phenotype
CTD_human
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
19943851
2010
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
LHGDN
However, the distribution of AQP4 -positve astrocytes differed markedly according to disease and was not necessarily related to brain edema , indicating that functions and regulation of AQP4 in human brains are multiple.
16133546
2005
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
RGD
Our data provide novel evidence that upregulation of these selected inflammatory mediators occurs very early and persists for several days after ICH, and that temporal patterns of expression of thrombin and AQP-4 are associated with brain edema formation.
20541575
2010
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
RGD
[Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema].
21560328
2011
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
RGD
These results indicate that increased AQP4 PM levels in perivascular astrocytic end-feet are likely critical to the development of brain edema in ALF.
20720509
2010
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
RGD
Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats.
20111877
2010
×
Entrez Id:
361
Gene Symbol:
AQP4
AQP4
0.230
Biomarker
phenotype
LHGDN
Accumulation of AQP4 IR may reflect its participation in the development of brain edema in human brains by playing a role in the transport of water not only through blood vessel walls but also through pial and ependymal surface of the brain.
12715185
2003
×
Entrez Id:
7422
Gene Symbol:
VEGFA
VEGFA
0.220
Biomarker
phenotype
RGD
[Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema].
21560328
2011
×
Entrez Id:
7422
Gene Symbol:
VEGFA
VEGFA
0.220
Biomarker
phenotype
RGD
Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction.
15879344
2005
×
Entrez Id:
358
Gene Symbol:
AQP1
AQP1
0.200
Biomarker
phenotype
RGD
[Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema].
21560328
2011
×
Entrez Id:
2147
Gene Symbol:
F2
F2
0.200
Biomarker
phenotype
RGD
Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema.
20541575
2010